Antimicrobial wide spectrum of action of the fluoroquinolones (diftorhinolon with the piperazine group in the quinolone ring). Effective bactericidal. It inhibits the enzyme activity of DNA gyrase involved in transcription and replication of bacterial DNA.
Moderately susceptible to the drug Proteus mirabilis, Proteus stuartii, Providencia rettgery, Pseudomonas aeruginosa (lomfloks effective gentamicin tsefatoksima, ceftazidime), Serratia Liquefaciens and marcesscens, Klebsiella oxytoca and ozaenae, Citrobacter freundii, Enterobacter aerogenes and agglomerans, Haemophilus parainfluenzae, Providencia alcalifaciens, Aeromonas hydrophila, Hafnia alvei, Mycobacterium tuberculosis, Chlamidia trachomatis, Bordetella pertussis, as well as some gram-positive aerobic bacteria: Staphylococcus aureus, Staphylococcus epidermidis (lomefloxacin significantly more effective than norfloxacin and nalidixic acid).
Drug resistance Streptococcus spp, Pseudomonas cepacia, Ureaplasma urealiticum and anaerobic bacteria. Vibrio cholerae and Vibrio paragemolitichesky susceptible to lomefloxacin. Ureaplazma urealyticum, Mycoplasma pneumonae and Mycoplasma hominis are also sensitive to the drug.
It has a pronounced what is anavar anti-TB activity. For most microorganisms operates at a low concentration.
Resistance is rare, mainly for staphylococci, Pseudomonas aeruginosa.
After receiving 400 mg lomefloxacin, the maximum serum concentration of about 3-5,2 mg / l was achieved within two hours. Accumulation was not observed in multiple dose designation 400 mg once daily or 300 mg three times a day for 7 days. With 400 mg / day was sensitive enterobacteria concentration above MIC 90 for at least 12 hours. The half of the plasma concentration varies from 7 to 9 hours. About 10% of the drug binds to the protein and quickly penetrates into most tissues. After the concentration of bile, prostate, lung tissue, bronchial secretion generally increased after plasmatic levels.
When taken orally, is absorbed from the gastrointestinal tract of 98% of the drug.
It penetrates the tissues and body fluids, which are higher concentrations than in plasma. Excreted by the kidneys, substantially unaltered (70-80%). The half-life of 8-9 hours. Patients with impaired renal function as the half-life and area under the curve of plasma concentration versus time (AUC) increases considerably, making it necessary to dose adjustment. When receiving a one-time drug is effective for 24 hours.
Infectious-inflammatory diseases caused by susceptible to malaria infections:
- uncomplicated and complicated urinary tract infections (cystitis, pyelonephritis, prostatitis);
- acute and chronic gonorrhea;
- acute and recurrent chlamydia, chlamydial conjunctivitis;
- infections of the lower parts of the respiratory tract, including exacerbation of chronic bronchitis, pneumonia;
- bone and joint infections, including chronic ostiomielit;
- acute and chronic purulent soft tissue infections;
- infectious enterocolitis, cholecystitis;
- infected wounds;
- obstetrical and gynecological infections;
- Prevention during transurethral intervention;
- cholera (severe course);
- tuberculosis (in the complex therapy with the main anti-TB drugs, as well as in resistance to anti-TB drugs)
If urinary tract infection is usually prescribed at 400 mg 1 time per day for no more than 10 days (uncomplicated form) or 10-14 days (complicated forms).
In acute gonorrhea administered 600 mg dose, in chronic gonorrhea – 600 mg 1 time per day for 5 days.
When urogenital chlamydiosis, including mixed bacterial and chlamydial infection is used at a dose of 400-600 mg 1 time a day for 28 days.
In acute and chronic purulent infections of soft tissue, infected wounds appoint 400 mg 1 time per day for 5-14 days.
Ostiomielite When used in a dose of 400-800 mg per day. The course of treatment up to 14 days.
For prophylaxis prior transurethral what is anavar surgery can be assigned to a single dose of 400 mg over 2-6 hours before the procedure.
In severe cholera appoint 400 mg 1 time a day for 5 days.
In tuberculosis used in a dose of 400 mg 2 times a day for 14-28 days, if necessary – is longer.
At the lower respiratory tract infections, acute bronchitis, bronchopneumonia administered at a dose of 400 mg per day for 10 days.
Elderly patients, in most cases the usual dose can be administered if they creatinine clearance less than 40 mL / min.
In patients with renal or hepatic insufficiency with creatinine clearance less than 40 mL / min, dose must be changed in accordance with the degree of renal failure. For the initial dose of 400 mg doses must follow 1 200 mg once a day for a course of treatment. There is no need to reduce the dose in patients with cirrhosis of the liver, if adequate renal function. Take the drug regardless of the meal.
Rare: nausea, diarrhea, epigastric pain, headache, sleep disturbances, mood swings, agitation, tremor, depression.
moderate effect photosensitivity can occur when excessive exposure to ultraviolet rays. In this case, treatment should cease. May cause arthropathy in the growing organism. Allergic reactions such as skin rash and other symptoms.
- Pregnancy and lactation;
- hypersensitivity to lomefloxacin and other quinolone;
- Children and adolescents under the age of 18 years
Be wary appoint patients with severe cerebral arteriosclerosis, epilepsy and other CNS disorders.
In case of occurrence against treatment of symptoms such as seizures, agitation, photophobia, confusion, hallucinations, the drug should be discontinued.
During treatment is recommended to avoid prolonged exposure to sunlight or ultraviolet light. When used in lactation period is necessary to resolve the issue of termination of breastfeeding.
May cause dizziness and impaired attention, so you should not engage in activities requiring coordination (to work on complex equipment, drive a car).
At the level of other quinolones may interfere with the metabolism of caffeine (tea / coffee), reducing clearance, half-life extending and enhancing caffeine overdose symptoms.
During the course of treatment is necessary to increase the amount of fluid consumed.
Do not use with polysaccharides antipepsinovym action or antacids that contain aluminum, magnesium, or within 4 hours before and 2 hours after administration of lomefloxacin, since it reduces its bioavailability. Mineral additives or vitamins or minerals containing iron, should not be taken within 2 hours after ingestion. There is evidence that the H2 antagonists (cimetidine, ranitidine) quinolones can what is anavar disrupt elimination, leading to increased half-life and AUC.
Unlike other quinolones not inhibit the metabolism of theophylline, the theophylline dose recalculation therefore not needed.