Loratadine belongs to antihistamines for systemic effects, blockers of H1-histamine receptors. It has anti-allergic, anti-itching, protivoekssudativnoe action.Reduces the permeability of capillaries, prevents tissue swelling, relieves spasms of smooth muscles.
Allergy effect develops within 30 minutes after ingestion, reaches a maximum at 8-12 hours and lasts 24 hours.
It has no effect on the central nervous system and is not addictive. Loratadine rapidly and completely absorbed from the gastrointestinal tract.The presence of food delays absorption. Maximum anavar for women serum concentration is reached within 1 hour after admission. Communication plasma protein is more than 95%. It is metabolized in the liver to the active metabolite descarboethoxyloratadine. It does not cross the blood-brain barrier. The half-life is about 8 hours in the elderly and in chronic alcoholism increases. Excreted in the bile and kidneys. In chronic renal failure and hemodialysis pharmacokinetics virtually unchanged.
Prevention and treatment of the following diseases:
- seasonal and perennial allergic rhinitis;
- allergic conjunctivitis;
- treatment of skin allergic diseases (including chronic idiopathic urticaria);
- pseudoallergy reaction;
- allergic reactions to insect bites.Contraindications
hypersensitivity to any component of tablets or suspensions.
WITH CARE should be applied to liver failure.
Data on the safety and efficacy of Lomilana ® in children under the age of 2 years there.
Pregnancy and lactation
Application Lomilana during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus. The drug is released in breast milk, so while taking the drug during lactation should decide the issue of termination of breastfeeding.
DOSAGE AND ADMINISTRATION
inside. You can also receive, along with food. If necessary, the tablet can be chewed. Wash down with water, milk. Adults and children over 12 years: 10 mg 1 time per day, ie, 1 or 2 tablet dosing spoon (10 ml) suspension of children 2 to 12 years (body weight or at least 30 kg) is 5 mg once a day, ie 1 Measuring spoon (5 ml) or 2.1 tablets. When the body weight of 30 kg or more – 10 mg -. 2 dosing spoons (10 ml) or 1 tablet 1 time a day for patients with impaired liver function or kidney failure initial dose is 10 mg – 1 tablet or 2 dosing spoons anavar for women slurry through day. For children under 12 years are recommended to use a suspension.
In adults: headache, dry mouth and somnolence, fatigue, nausea, gastritis. Rarely observed hepatic dysfunction, allergic reactions (hives), anaphylactic reactions, alopecia.
In children (rare). Headaches, nervousness, sedation
frequency of these side effects with Lomilana ® was at the same level as that of placebo.
Symptoms: Headache, drowsiness, palpitations, which can last a long time. No specific antidote.
When receiving an excessive amount should the drug from the gastrointestinal tract and can be removed quickly as possible to reduce its absorption (gastric lavage, activated charcoal).
With simultaneous use of ketoconazole and cimetidine loratadine concentration in the blood rises. Simultaneous treatment with inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, tricyclic antidepressants) reduces the effectiveness of loratadine.
The drug should be discontinued at least two days before the skin allergy tests, as may influence the results.
Data about the negative impact anavar for women at recommended doses on the ability to drive a car or operate machinery is not. However, patients who exceeded the dose or marking non-standard effects while taking Lomilana, care must be taken when engaging in potentially hazardous activities that require high concentration and speed of reactions