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Antimicrobial group of fluoroquinolones with a broad spectrum of activity. Effective bactericidal. Norfloxacin is active against most Gram-negative microorganisms: Escherichia coli, Salmonella spp, Shigella spp, Proteus spp, Morganella morganii, Klebsiella spp….(including Klebsiella pneumoniae), Enterobacter spp., Serratia marcescens, Citrobacter spp., Yersinia enterocolitica, Providencia stuartii, Haemophilus influenzae, Pseudomonas aeruginosa. It is anavar for sale also active against certain gram-positive bacteria (in particular Staphylococcus spp.), Against organisms which produce beta-lactamase. Norfloxacin less effective against Acinetobacter spp. and Enterococcus spp. and ineffective against anaerobic bacteria and streptococci.Pharmacokinetics Absorption After oral drug rapidly, but not completely (30-40%) is absorbed from the gastrointestinal tract. The maximum serum concentration observed after 1-2 h. Distribution Prior norfloxacin 67% of blood plasma penetrates into peripheral tissues. concentrations in excess plasma, observed in the bile ducts, gall bladder, liver, kidney and prostate. The drug does not cross the blood-brain barrier. Plasma protein binding is about 14%. Elimination half-life of 3.5-6.5 hours. About 80% excreted by the kidneys, 20% is excreted unchanged through the intestines.

Indications
Treatment of infectious and inflammatory diseases caused by susceptible organisms, including .:

 

  • urinary tract infections;
  • genital infections;
  • gonococcal infection;
  • Gastrointestinal infection;
  • Prevention of sepsis in patients with neutropenia;
  • travelers’ diarrhea.Dosing and Administration
    norfloxacin taken orally on an empty stomach (at least 1 hour before or 2 hours after meals) and washed down with plenty of liquid. In acute uncomplicated cystitis appoint 200-400 mg 2 times / day for 3-5 days. in acute urinary tract infections – 400 mg 2 times / day for 7-10 days. in recurrent or chronic recurrent urinary tract infections – 400 mg 2 times / day for 4 weeks and for 400 mg / day to 12 weeks case of recurrence. in infections of genitals – on 400-600 mg 2 times / day for 7 days. in acute uncomplicated gonococcal infections – administered 800 mg once daily. For the prevention of sepsis in neutropenic patients – 400 mg 3 times / day for 8 weeks. in the digestive tract infections – 400 mg 2 times / day for 3-5 days. For the prevention of bacterial diarrhea epidemic in disadvantaged areas -. 400 mg 1 time / day Patients with hepatic insufficiency and creatinine clearance 10-30 ml / min prescribed 400 mg 1 time / day.

     

    Side effect On the part of the digestive tract, liver: nausea, anorexia, diarrhea; perhaps transient increase in liver transaminases, alkaline phosphatase, lactate dehydrogenase. On the part of the central nervous system, the psyche: headache, dizziness, fatigue, drowsiness, restlessness, irritability, anxiety, confusion, hallucinations, depression, tinnitus. From the musculoskeletal skeletal system: in some cases – tendonitis, tendon rupture. From the laboratory readings: possible decrease in hematocrit, eosinophilia, leucopenia, elevated serum creatinine concentration in the plasma. Allergic reactions: seldom – urticaria, anavar for sale rash, pruritus, anaphylactic shock.

    Contraindications

  • pregnancy;
  • lactation (breastfeeding);
  • childhood and adolescence to 18 years;
  • Hypersensitivity to norfloxacin or other drugs of fluoroquinolones group.Special instructions:
    The appointment of norfloxacin during lactation should decide the issue of termination of breastfeeding.
    With care prescribe a drug to patients with epilepsy, seizures seizures in history, with severe renal impairment.
    In the period of treatment patients should receive adequate amounts of fluids (under the control of diuresis ).
    During therapy, norfloxacin was an increase in prothrombin index. During the surgery should monitor the status of the blood coagulation system.
    During treatment with norfloxacin should avoid exposure to direct sunlight.
    If you have pain in the tendons, or the first signs of tenosynovitis recommend repeal the drug.

    Effects on ability to drive vehicles and management mechanisms .
    In connection with the possible emergence of dizziness, patients taking norfloxacin, caution should be exercised when driving and busy with other potentially hazardous activities that require increased attention and psychomotor speed reactions (especially with simultaneous use of alcohol) .

    Interaction with other drugs
    With simultaneous use of norfloxacin with theophylline and cyclosporine may increase the concentrations of theophylline and cyclosporine in plasma.
    With the simultaneous use of norfloxacin with warfarin may increase the therapeutic effect of the latter.
    Simultaneous treatment with norfloxacin and antacids reduce the intensity of the absorption of norfloxacin. In this regard, the drug should be taken 1-2 hours before or at least 4 hours after the administration of these drugs.

    Overdose
    symptoms: dyspeptic disorders anavar for sale (nausea, vomiting, diarrhea), in more severe cases – dizziness, fatigue, confusion, convulsions.
    Treatment: gastric lavage, careful observation of the patient, symptomatic therapy. It is necessary to ensure a sufficient flow of fluid in the body, while maintaining an appropriate diuresis.

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