Loratadine anavar cycle for women belongs to antihistamines for systemic effects, blockers of H 1 histamine receptors. It has anti-allergic, anti-itching, protivoekssudativnoe action. Reduces the permeability of capillaries, prevents tissue swelling, relieves spasms of smooth muscles. Allergy effect develops within 30 minutes after ingestion, reaches a maximum at 8-12 hours and lasts 24 hours. It has no effect on the central nervous system and is not addictive. In by oral administration loratadine is rapidly and completely absorbed from the gastrointestinal tract. The presence of food slows the absorption of the drug without affecting its clinical effect. It is metabolized in the liver to the active metabolite descarboethoxyloratadine, which accounts for a large part of the clinical effect. The time to reach maximum concentration of loratadine and descarboethoxyloratadine plasma is 1-1.5 hours and 1,5-3,7 hours respectively. Loratadine and its active metabolite is bound to plasma Bellamy 97-99% and 73- 76% respectively. Poluraspredeleniya period of loratadine and its active metabolite in plasma, respectively, is about 1 and 2 hours. The average half-life of 8.4 hours for loratadine (in the range of from 3 to 20 hours) and 28 hours (in the range of from 8.8 to 92 hours) for the major active metabolite. In chronic liver failure, or alcoholic liver disease half-life is increased in proportion to the severity of disease. About 40% of the dose excreted by the kidneys and 42% – in the intestine within 10 days, mostly in the form of conjugated metabolites. 27% of the dose excreted by the kidneys within 24 hours. In chronic renal failure and hemodialysis pharmacokinetics virtually unchanged. Loratadine and its metabolite in breast milk stand.
Prevention and treatment of the following diseases:
- seasonal and perennial allergic rhinitis;
- allergic conjunctivitis;
- treatment of skin allergic diseases (including chronic idiopathic urticaria);
- pseudoallergy reaction;
- allergic reactions to insect bites.CONTRAINDICATIONS
- Hypersensitivity to any component of the drug.
- Phenylketonuria (lozenges Solo contain aspartame, which is a source of phenylalanine).
- Children weighing less than 30 kg.
- Hereditary galactose intolerance, fructose, Lapp lactase deficiency or malabsorption syndrome glucose-galactose.
- Liver failure (for this formulation, 10 mg).Pregnancy and lactation
Application anavar cycle for women Solo during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus. The drug is released in breast milk, so while taking the drug during lactation should decide the issue of termination of breastfeeding.
DOSAGE AND ADMINISTRATION
inside. Tablets for sucking Solo can be taken regardless of mealtime. Adults and children over 12 years: 1 tablet for sucking (10 mg), 1 per day. The maximum duration of self-treatment is 10 days. Children under 12 years of age with a body weight greater than 30 kg: 1 tablet for sucking (10 mg), 1 per day. Elderly patients with renal insufficiency not require dose adjustment.
Headache, dry mouth and somnolence, fatigue, nausea, gastritis. Rarely observed liver function abnormalities, allergic reactions (rash), anaphylactic reaction, alopecia, dizziness, tachycardia, increased nervous irritability. Besides the above listed children may develop sedation.
Adverse events occurred at approximately the same frequency as that of the application to placebo.
Symptoms: Headache, drowsiness, palpitations, which can last a long time. No specific antidote.
It is recommended gastric lavage and reception of adsorbents (activated charcoal). Anavar cycle for women Solo does not appear in hemodialysis.
INTERACTION WITH OTHER DRUGS
Does not increase the alcohol effects on the central nervous system. In a joint reception with ketoconazole, erythromycin or cimetidine was an increase in the concentration of loratadine and its metabolite in plasma, but this increase did not show clinically, including ECG data.
The drug should be discontinued at least two days before the skin allergy tests, as Lomilan ® Solo may have an impact on their results.
It should be handled carefully lozenges Lomilan ® Solo and take them with wet hands.